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HOW IT WORKS

Rebinyn® is an extended half-life treatment, which means it works in your body longer to control bleeds. The technology used to extend the half-life of Rebinyn® is called PEGylationa or “PEG” for short.

aPEG=polyethylene glycol.

Abdiel lives with hemophilia B and uses Rebinyn

> > How It Works

HOW IT WORKS

Rebinyn® is an extended half-life treatment, which means it works in your body longer to control bleeds. The technology used to extend the half-life of Rebinyn® is called PEGylationa or “PEG” for short.

aPEG=polyethylene glycol.

WHAT IS PEG?

WHAT IS PEG?

PEG is the technology behind having a longer half-life.

PEG is the technology behind having a longer half-life.

HOW DOES PEGYLATION WORK?

HOW DOES PEGYLATION WORK?

The PEG molecule is designed to attach to a specific part of Rebinyn®

GlycoPEGylation keeps Rebinyn® in your blood longer to stop bleeding

Rebinyn® releases active FIX similar to human FIX

  • Animals given repeat doses of Rebinyn® showed Polyethylene Glycol (PEG) in certain cells in the brain. The potential human implications of these animal tests are unknown.
Two Hemophilia Community Liaisons

WE'RE HERE TO HELP

Wondering about Rebinyn® or living with hemophilia B? Our Rare Blood Community Liaisons (RBCLs) are here to answer any questions you may have and connect you with the resources you need.

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WE'RE HERE TO HELP

Wondering about Rebinyn® or living with hemophilia B? Our Rare Blood Community Liaisons (RBCLs) are here to answer any questions you may have and connect you with the resources you need.

Let's Connect

DESIGNED WITH SAFETY IN MIND

In clinical studies, Rebinyn® was shown to be safe and effective.

four Rebinyn vials

See Our Safety Profile

RESOURCES FOR YOU

These materials can help you stay educated about bleeding disorders.

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Selected Important Safety Information

What is the most important information I need to know about Rebinyn®?

  • Do not attempt to do an infusion yourself unless you have been taught how by your healthcare provider or hemophilia treatment center. Carefully follow your healthcare provider’s instructions regarding the dose and schedule for infusing Rebinyn®.

Who should not use Rebinyn®?
Do not use Rebinyn® if you:

  • are allergic to Factor IX or any of the other ingredients of Rebinyn®.
  • are allergic to hamster proteins.
     

Indications and Usage

What is Rebinyn®, Coagulation Factor IX (Recombinant), GlycoPEGylated?
Rebinyn® is an injectable medicine used to replace clotting Factor IX that is missing in patients with hemophilia B. Rebinyn® is used to treat, prevent, or reduce the frequency (number) of bleeding episodes in people with hemophilia B. Your healthcare provider may give you Rebinyn® when you have surgery. Rebinyn® is not used for immune tolerance therapy.

Important Safety Information

What is the most important information I need to know about Rebinyn®?

  • Do not attempt to do an infusion yourself unless you have been taught how by your healthcare provider or hemophilia treatment center. Carefully follow your healthcare provider’s instructions regarding the dose and schedule for infusing Rebinyn®.

Who should not use Rebinyn®?
Do not use Rebinyn® if you:

  • are allergic to Factor IX or any of the other ingredients of Rebinyn®.
  • are allergic to hamster proteins.

What should I tell my healthcare provider before using Rebinyn®?
Tell your healthcare provider if you:

  • have or have had any medical conditions.
  • take any medicines, including non-prescription medicines and dietary supplements.
  • are nursing, pregnant, or plan to become pregnant.
  • have been told you have inhibitors to Factor IX.

How should I use Rebinyn®?

  • Rebinyn® is given as an infusion into the vein.
  • Call your healthcare provider right away if your bleeding does not stop after taking Rebinyn®.
  • Do not stop using Rebinyn® without consulting your healthcare provider.

What are the possible side effects of Rebinyn®?

  • Common side effects include infusion site reaction (bruising, bleeding, swelling, pain, or redness), itching, and rash.
  • Your body can also make antibodies called “inhibitors” against Factor IX, including Rebinyn®, which may stop Rebinyn® from working properly. Your healthcare provider may need to test your blood for inhibitors from time to time.
  • Call your healthcare provider right away or get emergency treatment right away if you get, for example, any of the following signs of an allergic reaction: hives, chest tightness, wheezing, difficulty breathing, and/or swelling of the face.
  • You may be at an increased risk of forming blood clots in your body, especially if you have risk factors for developing blood clots. Call your healthcare provider if you have chest pain, difficulty breathing, leg tenderness, or swelling.
  • Animals given repeat doses of Rebinyn® showed Polyethylene Glycol (PEG) in certain cells in the brain. The potential human implications of these animal tests are unknown.
     

Please click here for Prescribing Information.

Rebinyn® is a prescription medication.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.