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GET EFFECTIVE PROTECTION IN SURGERY

Rebinyn® provided
100% success rate in bleed control during surgery.a

aResults shown are from the surgery clinical study, which included 13 previously treated adolescent and adult patients. Patients received 1 infusion of Rebinyn® 80 IU/kg on the day of their surgeries. At the doctor’s discretion, patients received infusions of Rebinyn® 40 IU/kg for up to 3 weeks after surgery. Across 13 surgical procedures (9 major), the success rate in bleed control during surgery was evaluated on a four-point scale of excellent, good, moderate, or poor. Treatment success was defined as excellent or good bleed control. 

BLEED PROTECTION YOU CAN COUNT ON

In all major and minor surgeries and procedures studied, doctors rated Rebinyn® as excellent or good in protecting their patients from bleeds.a

REBINYN® PROVIDED

Success rate in bleed control during major surgery
Abdiel leaning on a pile of wood logs

THE POWER TO CONTROL BLEEDS

THE POWER TO CONTROL BLEEDS

Studies show that Rebinyn® provides effective bleed control for children, adolescents, and adults.

Learn About Bleed Control

RESOURCES FOR YOU

These materials can help you stay educated on bleeding disorders.

Resources

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DESIGNED WITH SAFETY IN MIND

In clinical studies, Rebinyn® was shown to be safe and effective.

three rebinyn vials

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Selected Important Safety Information

What is the most important information I need to know about Rebinyn®?

  • Do not attempt to do an infusion yourself unless you have been taught how by your healthcare provider or hemophilia treatment center. Carefully follow your healthcare provider’s instructions regarding the dose and schedule for infusing Rebinyn®.

Who should not use Rebinyn®?
Do not use Rebinyn® if you:

  • are allergic to Factor IX or any of the other ingredients of Rebinyn®.
  • are allergic to hamster proteins.
     

Indications and Usage

What is Rebinyn®, Coagulation Factor IX (Recombinant), GlycoPEGylated?
Rebinyn® is an injectable medicine used to replace clotting Factor IX that is missing in patients with hemophilia B. Rebinyn® is used to treat, prevent, or reduce the frequency (number) of bleeding episodes in people with hemophilia B. Your healthcare provider may give you Rebinyn® when you have surgery. Rebinyn® is not used for immune tolerance therapy.

Important Safety Information

What is the most important information I need to know about Rebinyn®?

  • Do not attempt to do an infusion yourself unless you have been taught how by your healthcare provider or hemophilia treatment center. Carefully follow your healthcare provider’s instructions regarding the dose and schedule for infusing Rebinyn®.

Who should not use Rebinyn®?
Do not use Rebinyn® if you:

  • are allergic to Factor IX or any of the other ingredients of Rebinyn®.
  • are allergic to hamster proteins.

What should I tell my healthcare provider before using Rebinyn®?
Tell your healthcare provider if you:

  • have or have had any medical conditions.
  • take any medicines, including non-prescription medicines and dietary supplements.
  • are nursing, pregnant, or plan to become pregnant.
  • have been told you have inhibitors to Factor IX.

How should I use Rebinyn®?

  • Rebinyn® is given as an infusion into the vein.
  • Call your healthcare provider right away if your bleeding does not stop after taking Rebinyn®.
  • Do not stop using Rebinyn® without consulting your healthcare provider.

What are the possible side effects of Rebinyn®?

  • Common side effects include infusion site reaction (bruising, bleeding, swelling, pain, or redness), itching, and rash.
  • Your body can also make antibodies called “inhibitors” against Factor IX, including Rebinyn®, which may stop Rebinyn® from working properly. Your healthcare provider may need to test your blood for inhibitors from time to time.
  • Call your healthcare provider right away or get emergency treatment right away if you get, for example, any of the following signs of an allergic reaction: hives, chest tightness, wheezing, difficulty breathing, and/or swelling of the face.
  • You may be at an increased risk of forming blood clots in your body, especially if you have risk factors for developing blood clots. Call your healthcare provider if you have chest pain, difficulty breathing, leg tenderness, or swelling.
  • Animals given repeat doses of Rebinyn® showed Polyethylene Glycol (PEG) in certain cells in the brain. The potential human implications of these animal tests are unknown.
     

Please click here for Prescribing Information.

Rebinyn® is a prescription medication.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.